Abstract: Innovations in quantum science and technology have enabled previously unforeseen levels of measurement and control over simple quantum systems comprised of atoms, electrons and photons. This talk will illustrate some of these advances with examples relevant to bio-imaging and precision sensing. For example, so-called quantum non-demolition measurements provide a foundation for next generation electron microscopes capable of low-damage imaging of biological samples such as proteins. Related non-demolition protocols for atoms in high finesse optical cavities are used to produce entangled states of more than 1000 ultra-cold atoms. These states are exploited to improve the performance of atomic clocks. Finally, atom de Broglie wave interference experiments with atomic wavepackets separated by distances as large as 54 cm (image below is the resulting interference pattern) are being used for new tests of gravity and quantum mechanics. These examples, and their possible impact on basic science and technology, will be discussed.