Dartmouth Events

MS Defense Talk by Dr. Qinxin Pan

Inferring Protein Structural Contacts from the Evolutionary Record -- the Advantage of Considering Amino-Acid Identities

Friday, March 28, 2014
Sudikoff 213
Intended Audience(s): Public
Categories: Lectures & Seminars

Covariance between amino acid at different residues of a protein family has been used to infer structural contacts. Different from conventional covariance-based approaches, direct-coupling analysis (DCA) is designed to disentangle direct and indirect correlations, enabling it to predict contacts accurately. Here, we show that in addition to the co-occurrence pattern between residues, the amino-acid identities underlying the residue pairs also provide information for structural contact prediction. We propose a framework that takes both evolutionary record and amino-acid identities into account and achieves better prediction accuracy than DCA across many protein families. In addition, we extend this framework to a recently emerged contact definition that is more structurally informative than previous ones. The contacts predicted by our approach could serve as reliable guides for protein structure prediction.

For more information, contact:
Gevorg Grigoryan

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