"Autophagy in Health and Disease"

Beth Levine, MD

Professor of Internal Medicine and Microbiology
Howard Hughes Medical Institute
Charles Cameron Sprague Distinguished Chair in Biomedical Science
Director, Center for Autophagy Research
UT Southwestern Medical Center

8:00 a.m. – 9:00 a.m.

Auditorium E, Rubin Building, Dartmouth-Hitchcock Medical Center

Co-sponsored by the MD/PhD Program and the Department of Medicine

Geisel School of Medicine at Dartmouth

Learning Objectives:

1. Explain the physiological functions of the cell biology pathway called autophagy

2. Examine roles that autophagy may play in health and disease

3. Discuss possible therapeutic strategies to treat human diseases by modulating autophagy.

Dr. Levine is internationally recognized as a leading authority in the field of autophagy. She received an A.B. from Brown University, a medical degree from Cornell University Medical College, and completed her postdoctoral training in Infectious Diseases/Viral Pathogenesis at the Johns Hopkins University School of Medicine. In 1993, she joined the faculty at Columbia University College of Physicians & Surgeons where she became Associate Professor of Medicine. In 2004, she became the Jay P. Sanford Professor and Chief of the Division of Infectious Diseases at UT Southwestern Medical Center. In 2011, she became the Director of a newly created Center for Autophagy Research at UT Southwestern and the Charles Cameron Sprague Distinguished Chair in Biomedical Science. Since 2008, she has been a Howard Hughes Medical Institute Investigator.  Dr. Levine’s laboratory has made fundamental discoveries that have helped to open up a new field of biomedical research: the role of autophagy in human health and disease. Her laboratory identified the mammalian autophagy gene, beclin 1, and defined a role for beclin 1 and the autophagy pathway in tumor suppression, antiviral immunity, development, cell death regulation, lifespan regulation, and exercise-induced metabolic effects. Dr. Levine has received numerous awards for her research, including the 2008 Edith and Peter O’Donnell Award in Medicine from The Academy of Medicine, Engineering and Science of Texas. She was elected to the National Academy of Sciences in 2013, and received the 2014 American Society of Clinical Investigation Stanley J. Korsmeyer award.

If you are unable to attend and would like to either view Grand Rounds live on your computer or if you would like to view it another time, please use this link.

http://med.dartmouth-hitchcock.org/education/dept_medicine_grand_rounds_live.html

Activity Codes will not be provided until the time of the presentation. Please email Jessica Kinzie with questions Jessica.d.kinzie@hitchcock.org

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** The Dartmouth-Hitchcock Medical Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education programs for physicians.**

** The Dartmouth-Hitchcock Medical Center designates this live activity for a maximum of 1 AMA PRA Category 1 Credit™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity. **